drug development

Mycoplasma pneumoniae with pathogenic genes replaced by biofilm-degrading ones enhance survival in a mouse model of ventilator-associated pneumonia.

This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.

After injecting moderate doses of the dissociative anesthetic into the animals, previously “awake” brain cells go dark, and those that had been dormant suddenly light up.

Thanks to continued weekly medications, a 16-month-old girl shows no symptoms of a severe genetic disease that typically kills children before they turn two.

The research has caveats, including side effects and a lack of durability in the benefits of a single dose.

The discovery could one day lead to the development of better antinausea medications.

Both Pfizer and GSK have shared preliminary data suggesting that their experimental vaccines can protect older adults and newborn infants from the virus.

Advanced genomic tools have provided biotech companies new approaches to help our furry friends—but experts say several limitations remain.

In clinical trials, the new inoculation demonstrated greater protection for children and people older than 45 than the existing dengue vaccine.

He was best known for his discovery that grapefruit juice makes some medications less effective or potentially dangerous.

Researchers overseeing the clinical trial for the first FDA-approved oral contraceptive claimed the drug gave the Puerto Rican participants power over their family planning. Critics claimed the women were exploited.

The Biogen-developed treatment, called lecanemab, appears to have a more clear-cut effect on slowing the disease than the company’s previous Alzheimer’s drug, Aduhelm.

A vaccine strategy involving formulation changes, an initial escalating dose, and a longer wait for booster immunization results in more-effective antibody production against HIV in rhesus monkeys, a study finds.

Researchers report that vaccination against proteins found on profibrotic cells reduced liver and lung fibrosis in laboratory rodents.