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Artist’s impression of stem cells. The cells have a transparent cell membrane on a pale blue background.
Overcoming Cancer Therapy Obstacles With Epitope Editing
Editing epitopes expressed on the surfaces of transplanted hematopoietic stem cells renders them resistant to AML treatments without affecting their critical functions.
Overcoming Cancer Therapy Obstacles With Epitope Editing
Overcoming Cancer Therapy Obstacles With Epitope Editing

Editing epitopes expressed on the surfaces of transplanted hematopoietic stem cells renders them resistant to AML treatments without affecting their critical functions.

Editing epitopes expressed on the surfaces of transplanted hematopoietic stem cells renders them resistant to AML treatments without affecting their critical functions.

News & Opinion

Brain tumor on an MRI scan
Machine Learning for Predicting Glioblastoma Prognosis
Tanvir Khan, PhD | Oct 4, 2023 | 3 min read
Researchers integrate scRNA-seq, spatial transcriptomics, and histology imaging data to show that spatial cellular architecture predicts glioblastoma prognosis.
Genetic engineering and digital technology concept.
A Machine Learning Tool Uncloaks the Hidden Sources of Cancer Cells
Rachael Moeller Gorman | Oct 5, 2023 | 4 min read
Researchers created a model that uses clinical testing data to locate the primary site of cancer cells with no known origin, likely improving survival.
Close-up image of fat cells
A Snapshot of How Obesity Transforms Fat
Aparna Nathan, PhD | Oct 5, 2023 | 3 min read
Spatial methods reveal immune cell formations in fat during early obesity.
Line drawings of Moungi Bawendi (left), Louis Brus (center), and Alexei Ekimov (right) from the shoulders up.
Nobel Prize in Chemistry for Quantum Dots
Hannah Thomasy, PhD | Oct 4, 2023 | 3 min read
Moungi Bawendi, Louis Brus, and Alexei Ekimov were awarded the Nobel Prize for their work on quantum dots, which has applications in electronics and biomedicine.
Black and gold sketch of the three prize winners.
Nobel Prize for Experiments With Light
Danielle Gerhard, PhD | Oct 3, 2023 | 4 min read
Anne L’Huillier, Pierre Agostini, and Ferenc Krausz received this year’s Physics award for creating tools for studying the world of electrons, with future applications in medical diagnostics.
Black and gold sketch of Katalin Karikó and Drew Weissman.
Nobel Prize for mRNA Vaccines
Danielle Gerhard, PhD | Oct 2, 2023 | 5 min read
Katalin Karikó and Drew Weissman received this year’s Physiology or Medicine award for their work on RNA biology and mRNA-based vaccines.
: Aerial view of a scattered pile of audio cassette tapes.
Regulating Insulin With Queen’s Greatest Hits 
Kamal Nahas, PhD | Oct 2, 2023 | 4 min read
Pop music balanced blood sugar levels in mice, thanks to implanted human cells rigged to release insulin using a sound-sensitive bacterial protein.
A three-dimensional rendered image of neuron cell network on black background.
Assembloids Unlock the Roles of Key Neurodevelopment Disease Genes
Aparna Nathan, PhD | Sep 27, 2023 | 3 min read
Brain-like tissue grown in a dish mimics critical periods for development and reveals how it can go wrong.
Flat blue line that becomes a pink jagged line and then a flat red line, on a black background.
Emerging from Silence: Capturing the First Heartbeat
Danielle Gerhard, PhD | Sep 27, 2023 | 5 min read
In the developing zebrafish, a noisy and asynchronous activity jumpstarts the heart’s journey to coordinated beating.
A doctor reaches out to touch a lung tumor, highlighted in red.
Silencing Epigenetic Complexes Re-sensitizes Drug-Resistant Cancer Cells
Rachael Moeller Gorman | Sep 25, 2023 | 4 min read
Researchers studying lung cancer cell lines found that chromatin remodeling underlies one type of osimertinib resistance.
The Vaginal Microbiome is Finally Getting Recognized
Hannah Thomasy, PhD, Drug Discovery News | Sep 25, 2023 | 10+ min read
Vaginal dysbiosis has long been a taboo subject, but studying and optimizing the vaginal microbiome could be a game changer for women's health.
3D medical illustration showing acute lymphoblastic leukemia cells and red blood cells in circulation.
Niche Interactions Lock Down Leukemia Cells
Deanna MacNeil, PhD | Sep 24, 2023 | 3 min read
Researchers unravel the mystery of epithelial to mesenchymal transition in acute lymphoblastic leukemia with co-culture techniques, CRISPR-screening, and RNA sequencing.
Lasker Award winner Piet Borst sits at his desk.
Piet Borst Wins a Lasker Award for Scientific Excellence
Laura Tran, PhD | Sep 21, 2023 | 7 min read
This year's Lasker~Koshland Award for Special Achievement was awarded to Piet Borst for his stellar work on cell organelles, trypanosomes, and cancer drug resistance.
Ribbon Protein Structure
Lasker Award for Revolutionizing Protein Structure Predictions
Laura Tran, PhD | Sep 21, 2023 | 6 min read
John Jumper and Demis Hassabis received this year’s 2023 Albert Lasker Basic Medical Research Award for their work on the artificial intelligence system AlphaFold, which changed the landscape of protein biology. 
Woman massaging pain in her left wrist.
The Extra X: How the Sex Chromosome Affects Autoimmunity Risk
Kamal Nahas, PhD | Sep 19, 2023 | 4 min read
What underlies the uneven burden of autoimmunity between the sexes has remained a mystery. Now, scientists found clues by turning to a key player on the X chromosome.
Epigenetic Marks May Cause Brain Tumor Formation
Jennifer Zieba, PhD | Sep 19, 2023 | 3 min read
Scientists established an epigenetic mouse model for glioma, providing insight into how epigenetics can initiate cancer.
Cropped view of senior man playing with puzzles
A Rare Genetic Mutation Protects Against Alzheimer's Disease
Hannah Thomasy, PhD, Drug Discovery News | Sep 17, 2023 | 4 min read
Data from a highly resilient individual guided researchers to new potential therapeutic targets.
2023 Ig Nobel Prize for Gripping Work on Dead Spiders
Meenakshi Prabhune, PhD | Sep 15, 2023 | 3 min read
Rice University researchers claimed the Ig Nobel Prize for upleveling biorobotics by transforming deceased spiders into robotic grippers.
Image of <em >Candida albicans</em> fungus.
A Fungus Plays Tug-of-war for Metal Ions
Laura Tran, PhD | Sep 14, 2023 | 3 min read
In the fight between hosts and fungal pathogens, scientists discovered how withholding manganese can cripple Candida albicans.
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