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June 2022, Issue 2 Table of Contents

Feature

Illustration of a syringe with a person falling out of a bottle of pills
Opioid Vaccines as a Tool to Stem Overdose Deaths
Tori Rodriguez | Jun 13, 2022 | 10+ min read
Researchers are turning to the immune system for help in treating addiction and preventing overdose.

Freeze Frame

Trichaptum abietinum growing on a pine log
Caught on Camera
Caught on Camera
See some of the coolest images recently featured by The Scientist

Infographics

Two prime editing guide RNAs (pegRNAs), deliver Cas9 enzymes to targeted regions of the genome.
Infographic: Two Guide RNAs Make for Large, Stable Insertions
Infographic: Two Guide RNAs Make for Large, Stable Insertions
A new technique goes beyond CRISPR and writes two complementary strands of DNA directly into the genome.
Vaccine illustration 
Infographic: Inducing Active Immunity Against Opioid Overdose
Infographic: Inducing Active Immunity Against Opioid Overdose
How scientists aim to induce an immune response against addictive drugs

Modus Operandi

Genetic Syndrome and Genetic Disorder, 3D illustration of science concept.
With Two RNA Guides, Editing Technique Writes Long DNA Insertions
With Two RNA Guides, Editing Technique Writes Long DNA Insertions
The approach, called GRAND, uses a second guide RNA to write complementary strands of DNA in targeted genomic locations, resulting in efficient insertions that can be hundreds of base pairs long.

Bio Business

Spraying spray bottle
Nasal Vaccines Are Commercially High Risk, Perhaps High Reward
Nasal Vaccines Are Commercially High Risk, Perhaps High Reward
Dozens of intranasally delivered vaccines targeting SARS-CoV-2 are in development. Could they pave the way for widespread nasal vaccination in the future?

Scientist to Watch

Ribonucleic acid strands consisting of nucleotides important for protein bio-synthesis
Katharina Höfer Probes the Machinery of Bacterial Gene Expression
Katharina Höfer Probes the Machinery of Bacterial Gene Expression
The molecular biologist studies how chemical modifications to RNA building blocks change the way RNA regulates complex cellular processes.

Reading Frames

Surgery tools from World War 1
An excerpt from The Facemaker
An excerpt from The Facemaker
This new book tells the fascinating story of plastic surgery’s unlikely origin on WWI battlefields.
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