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Electron micrograph of cancer cell with T cells stuck to the side, colored in red
Translation of “Jumping Genes” Creates Cancer Therapy Targets
Researchers find many tumor-specific antigens form when cancer genes and transposable elements link up.
Translation of “Jumping Genes” Creates Cancer Therapy Targets
Translation of “Jumping Genes” Creates Cancer Therapy Targets

Researchers find many tumor-specific antigens form when cancer genes and transposable elements link up.

Researchers find many tumor-specific antigens form when cancer genes and transposable elements link up.

tumor antigens

Red T cell
Jumping Genes Put a Target on Cancerous Cells
Natalia Mesa, PhD | Feb 14, 2023 | 4 min read
Two studies find that tumor-specific antigens are often peptides that result from a splicing event between exons and transposable elements.
2022 Top 10 Innovations 
2022 Top 10 Innovations
The Scientist Staff | Dec 12, 2022 | 10+ min read
This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.
salmonella bacteria 3d illustration
Salmonella Injection Helps the Mouse Immune System Kill Tumors
Dan Robitzski | May 16, 2022 | 3 min read
Nanoparticle-coated bacteria can capture tumor antigens and deliver them to immune cells, triggering a response that improved survival rates in mice.
Illustration showing how following radiation therapy, which triggers the release of cancer-specific antigens, researchers injected Salmonella typhimurium bacteria covered in positively charged nano- particles near tumors in mice.
Infographic: Salmonella Shuttle Tumor Antigens to Immune Cells
Dan Robitzski | May 16, 2022 | 1 min read
Nanoparticle-coated bacteria carry cancer-derived proteins to dendritic cells, enabling the immune system to launch a response in a mouse model.
A stained tissue sample of metastatic pancreatic cancer
Tetanus Immunity Protects Mice Against Pancreatic Cancer
Amanda Heidt | Mar 24, 2022 | 3 min read
Because most people are vaccinated against tetanus as children, delivering benign bacteria carrying a tetanus antigen into pancreatic tumors makes them visible to memory cells in the immune system, researchers report.
Discover How to Accelerate and Improve CAR-T therapy development
Advances in Solid Tumor Immunotherapies
Sartorius | Oct 6, 2021 | 1 min read
By screening for novel tumor targets, researchers build better CAR-T cell therapies.
Enhancing the Efficacy of CAR-T Cell Therapies
The Scientist Creative Services Team in Collaboration with IsoPlexis | Jun 29, 2021 | 1 min read
Jessica Morris will discuss strategies to improve CAR-T cell targeting, activation, and killing capabilities.
Bispecific Antibodies Treat Cancer in Mouse Models
Abby Olena, PhD | Mar 5, 2021 | 4 min read
A trio of papers shows that specialized antibodies can direct T cells to destroy cells that display portions of mutant cancer-related proteins, as well as T cells that have become cancerous themselves.
CAR T cells, oncolytic virus, CD19, mouse model, solid cancer, liquid cancer, tumor, immune response, immunotherapy, T cell, treatment
Immunotherapy Combo Reduces Solid Tumors in Mice
Amanda Heidt | Sep 9, 2020 | 5 min read
When tumor cells are infected with an oncolytic virus carrying a modified CD19 gene, they become targets for CAR T cells engineered to recognize this molecular marker.
dendritic cell t cell immunology cancer immunotherapy in situ vaccine
In Situ Vaccination: A Cancer Treatment a Century in the Making
Emma Yasinski | Jul 25, 2019 | 6 min read
Injecting immunostimulants directly into the tumor is not a new strategy to stimulate the immune system, but the approach has seen a surge of interest in recent years.
Tracking the Evolutionary History of a Tumor
Amber Dance | Apr 1, 2017 | 7 min read
Analyzing single cell sequences to decipher the evolution of a tumor
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