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Tuning T Cells
An often overlooked property of the tumor environment shapes T cell function and may improve T cell therapies.
Tuning T Cells
Tuning T Cells

An often overlooked property of the tumor environment shapes T cell function and may improve T cell therapies.

An often overlooked property of the tumor environment shapes T cell function and may improve T cell therapies.

T cells

Dendritic Cell activate T cells, trigger immune responses, they are responsible of cells protection of the body.
Circadian Signaling Affects T Cell Responses to Vaccination
Nathan Ni, PhD | Aug 9, 2023 | 3 min read
Annie Curtis’s research team revealed how circadian rhythm-regulated mitochondrial metabolism drives dendritic cell antigen presentation activity.
3D rendered medical illustration of T cells trying to subdue cancer cells.
How Tumors Tire Out T Cells
PhenomeX | Jul 19, 2023 | 1 min read
Researchers investigated how cancer antigenicity drives unique forms of T cell exhaustion and hypofunctionality.
Neoantigen Prediction for Precision Immunotherapies
Neoantigen Prediction for Precision Immunotherapies 
The Scientist’s Creative Services Team | 2 min read
Learn about the tools and resources researchers use to define, discover, and deploy anti-tumor immunotherapies.
Illustration of a virus
Vaccines: Sex Matters
Niki Spahich, PhD | Jun 1, 2023 | 3 min read
Male patients who recover from mild COVID-19 have baseline immune states primed to mount stronger responses to future challenges than female patients.
Scientist pipetting at the bench in white coat and purple gloves
Chek-Mate for Gliomas
Aparna Nathan, PhD | May 22, 2023 | 3 min read
New research may make immunotherapy possible for hard-to-treat brain tumors.
Discover how counterflow centrifugation streamlines cell therapy workflows
Closed Cell Processing Systems for Cell Therapy Workflows
Thermo Fisher Scientific | 1 min read
Closed systems increase cell therapy manufacturing process efficiency.
Engineered T cells attacking a cancer cell
Helping Engineered T Cells Find Their Way to Tumors
Nele Haelterman, PhD | Apr 18, 2023 | 3 min read
Susan Thomas discusses how her team engineered a microfluidic device to screen for T cells with improved homing capability to tumor cells. 
An artistic rendering of SARS-CoV-2 made to look like stained glass
SARS-CoV-2 Infection Can Alter Future Immune Reponses
Niki Spahich, PhD | Feb 22, 2023 | 3 min read
Males recovered from mild COVID-19 have baseline immune states primed to mount stronger responses to future challenges.
Explore the importance of cellular diversity in health and disease through single cell resolution.
Single Cell Resolution Reveals Cellular Diversity
The Scientist’s Creative Services Team and 10x Genomics | 1 min read
Access to single cell resolution reveals new insights into how the human body and its cells operate during health and disease.
Closeup of a pair of hands in blue gloves holding a white mouse and injecting it with an amber colored liquid.
Opioids Recruit the Immune System to Cause Withdrawal Symptoms
Dan Robitzski | Jan 25, 2023 | 6 min read
A study finds that T cells induced by heroin cross the blood-brain barrier to wreak havoc on the brain, hinting at new ways to prevent withdrawal.
Human brain stock photo
New Insight into Brain Inflammation Inspires New Hope for Epilepsy Treatment
Deanna MacNeil, PhD | Jan 23, 2023 | 3 min read
Clinicians and researchers teamed up to investigate how inappropriate proinflammatory mechanisms contribute to the pathogenesis of drug-refractory epilepsy.
Peripheral blood mononuclear cells surrounded by red blood cells in circulating blood.
Accelerating Immune Research with Cryopreserved Peripheral Blood Mononuclear Cells
The Scientist’s Creative Services Team and MilliporeSigma | 3 min read
Commerically-available peripheral blood mononuclear cells offer a well-characterized, accessible, and consistent model for immunology and therapeutic development.
Illustration showing immunology during pregnancy
Infographic: How Immunology Can Influence Pregnancy Outcomes
Tobias R. Kollmann, Arnaud Marchant, and Sing Sing Way | Nov 14, 2022 | 3 min read
Pregnancy-induced changes in the immune system are key to a successful birth. Understanding those changes could allow researchers to protect both mother and child.
Illustration of pregnancy and the immune system
Modulating Immunity to Improve Pregnancy Outcomes
Tobias R. Kollmann, Arnaud Marchant, and Sing Sing Way | Nov 14, 2022 | 10+ min read
Aberrant immune activation, the main cause of prematurity and stillbirths, could be preventable through interventions such as maternal vaccination. 
The adaptive and innate immune responses collaborate to attack T-cell resistant cancer cells
LabTalk Podcast - Phagocidal Macrophages: A New Battle Tactic Against Resistant Cancers
The Scientist’s Creative Services Team and 10x Genomics | 1 min read
The adaptive and innate immune responses collaborate to attack T-cell resistant cancer cells.
Orange colony of bacteria on red medium
Skin Bacteria May Trigger Lupus: Mouse Study
Natalia Mesa, PhD | Oct 28, 2022 | 3 min read
Staphylococcus aureus appears to be the culprit.
News feature
Vector image of black body with head surrounded by white clouds
Multiple Possible Causes of Long COVID Come into Focus
Natalia Mesa, PhD | Sep 28, 2022 | 10+ min read
Recent studies have lent support for a variety of hypotheses explaining the debilitating symptoms affecting millions of people after SARS-CoV-2 infection.  
Understand Immune Cell Function in Cancer
Understanding Immune Cell Function in Cancer
The Scientist’s Creative Services Team and Isoplexis | 1 min read
Explore how scientists characterize immune cell functional behavior in response to cancer, and how they harness this information for therapeutic purposes.
jigsaw puzzle with magnifying glass over the word "metastasis" 
Breast Cancer Cells Retrain T Cells to Invade Specific Tissues
Nele Haelterman, PhD | Sep 26, 2022 | 3 min read
Scientists discover tumor-associated T cells that drive breast cancer metastasis to lymph nodes.
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