senescence

Skin moles that sprout thick, long hairs produce signaling molecules that stimulate hair follicle stem cells to initiate new hair growth. This discovery may make baldness a thing of the past.

Researchers learned how IGFBP7, a senescence signaling protein and biomarker, promotes cardiac remodeling and cellular aging.

Mice that received the stem cell–derived treatment were less frail compared with controls, a study reports.

Immune cells deliver packages of telomeres to T cells, helping them retain their virus-fighting function over time, research suggests.

An analysis of more than half a million trees reveals that many species begin to taper off seed production once they hit a certain size.

A handful of clinical trials are underway to find out whether drugs that target senescent cells can slow the ravages of old age.

The accumulation of zombie-like cells seems to accelerate aging and promote aging-related disease. Researchers are trying to figure out how.

Genes related to the immune system stay active throughout the tree’s life.

The elimination of these glia in the mouse brain ameliorated the development of Parkinsonian neuropathologies induced by the pesticide toxin paraquat.  

Ned Sharpless currently leads the cancer center at the University of North Carolina, Chapel Hill.

Increasing the expression of an RNA splicing factor mimics dietary restriction, prolonging life in nematodes. 

A study on human cells reveals how cellular aging affects the 3-D architecture of chromosomes.

How do we age, and can we slow it down?

Obesity drives an alteration of the gut microbiome, leading to the secretion of metabolites associated with the development of liver cancer.

New findings challenge long-held views about the mechanism yeast cells use to live forever.

By selectively killing senescent cells, researchers can slow the decline of health in aging mice.