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Viral Vector Platforms for Gene Therapy
Viral Vector Platforms for Gene Therapy
In both the laboratory and clinic, scientists harness viral genetic transfer capabilities to develop gene therapies that modulate cellular function.
In both the laboratory and clinic, scientists harness viral genetic transfer capabilities to develop gene therapies that modulate cellular function.
retrovirus
Ancient Viral DNA Helps Mouse Brains Fight Infection
Natalia Mesa, PhD | Oct 24, 2022 | 3 min read
Mammals that give birth to live young may have evolved to make use of the remnants of viruses in their genomes to ward off pathogens, a study suggests.
Participant’s Diagnosis Halts Gene Therapy Clinical Trial
Amanda Heidt | Aug 12, 2021 | 3 min read
The FDA pauses the research program on a lentivirus-based treatment for a rare neurological condition after a patient developed a bone marrow disorder that could presage leukemia.
Uncovering Ancient Residual DNA
The Scientist’s Creative Services Team | 1 min read
A look at how ancient events crafted modern human DNA and their potential impact on human health.
Pioneering Molecular Virologist Flossie Wong-Staal Dies
Amanda Heidt | Jul 14, 2020 | 3 min read
The University of California, San Diego, researcher helped identify the HIV retrovirus responsible for AIDS and developed treatments still in use today.
Can Viruses in the Genome Cause Disease?
Katarina Zimmer | Jan 1, 2019 | 10+ min read
Clinical trials that target human endogenous retroviruses to treat multiple sclerosis, ALS, and other ailments are underway, but many questions remain about how these sequences may disrupt our biology.
Ancient Origins of Retroviruses
Tracy Vence | Jan 11, 2017 | 1 min read
Foamy-like endogenous retroviruses may have emerged more than 450 million years ago, according to an analysis.
Viral Remnants Help Regulate Human Immunity
Jyoti Madhusoodanan | Mar 3, 2016 | 3 min read
Endogenous retroviruses in the human genome can regulate genes involved in innate immune responses.
Endogenous Retrovirus Active in ALS
Jef Akst | Sep 30, 2015 | 3 min read
Researchers uncover evidence that a retrovirus embedded within the human genome may play a role in the pathology of amyotrophic lateral sclerosis.
The Origins of O
Kerry Grens | May 1, 2015 | 2 min read
A strain of HIV that has afflicted more than 100,000 people emerged from gorillas.
Viral Protector
Jef Akst | Apr 21, 2015 | 1 min read
A retrovirus embedded in the human genome may help protect embryos from other viruses, and influence fetal development.
Repurposed Retroviruses
Ruth Williams | Dec 18, 2014 | 3 min read
B cells have commandeered ancient viral sequences in the genome to transmit antigen signals.
Genome Editing Cuts Out HIV
Kerry Grens | Jul 21, 2014 | 3 min read
Researchers use the CRISPR/Cas9 method to remove the virus from the host genome in human cell lines.
HIV Returns in Patients Thought Cured
Abby Olena, PhD | Dec 10, 2013 | 2 min read
The virus is back in two patients in Boston who received bone-marrow transplants and did not have detectable levels of virus for months.
Unexpected Origin of an Avian Virus
Ruth Williams | Aug 26, 2013 | 3 min read
The transmission of reticuloendotheliosis viruses from mammals to birds was most likely an unexpected consequence of medical research.
Two Patients Rid of HIV?
Kate Yandell | Jul 3, 2013 | 2 min read
Bone marrow transplants appear to have eliminated HIV from Boston cancer patients.
Cure for HIV-Infected Newborns?
Kate Yandell | Jun 27, 2013 | 2 min read
A clinical trial will test the strategy a Mississippi doctor used to cure an infant.
HIV Remission for 14 Patients
Kate Yandell | Mar 16, 2013 | 1 min read
The virus was largely stomped out in adults who started treatment soon after infection.
Ancient Viruses Wreak New Havoc
Beth Marie Mole | Oct 23, 2012 | 3 min read
Viral DNA in mice genomes may lead to cancer in immune-compromised animals.
Chronic Fatigue Researcher Fired
Edyta Zielinska | Oct 4, 2011 | 1 min read
Researcher who found connection between virus and chronic fatigue fired for not releasing her research samples.