protein folding

From humble yet ingenious beginnings to Nobel recognition, cryogenic electron microscopy (cryo-EM) provides insights into scientific questions that other technologies are unable to answer.

When Gaurav Ghag realized that he had replicated a calculation error in every experiment during four years of his graduate research, he initially thought that his career had unraveled with his protein.  

Machine learning can be harnessed to synthesize artificial light-bearing enzymes that actually work in cells.

Three prizes were awarded to six researchers working across the life sciences on cellular organization, protein structure, and the genetic underpinnings of a chronic sleep disorder.

An RNA-modifying enzyme passed to daughter cells during budding allows yeast cells to switch between faster- and slower-growing phenotypes.

Conservation of structures and functions between single-celled fungi and human cells allow researchers to probe the brain.

The AlphaFold program from AI firm DeepMind has amassed a huge database of protein structures from humans and model organisms.

An unfolded protein found in human milk shows promise in early clinical trials to treat bladder cancer.

Research by the Stanford University School of Medicine professor revealed how newly formed strings of amino acids fold into complex three-dimensional shapes.

The technology solves proteins’ 3-D shapes in minutes, when traditional methods may take years.

Mechanically sensitive proteins called gellins sense and respond to protoplasm flowing out of severed hyphae, quickly sealing up injuries in these root-like structures of fungi.

Flexible proteins appear to protect molecules from becoming denatured in extreme conditions such as heat and from clumping up, as happens in some neurodegenerative diseases.

The creativity of citizen scientists could help researchers design proteins that may be able to fight the SARS-CoV-2 virus.

A synthetic genetic tool called yTRAP allows high-throughput detection of protein aggregates in cells.
 

Strategies for targeting intrinsically disordered proteins

Lila Gierasch uses biochemical tools to understand how linear chains of amino acids turn into complex three-dimensional structures.