preclinical

Personalized stem cells improved motor symptoms and depression signs in monkeys modeling Parkinson’s disease, paving the way for trials in human patients.

RNA editing has been in DNA editing’s shadow for nearly a decade, but recent investments in the technology could bring it into the limelight.

The Australian biomedical research community is stunned by the announced wind-down of the country’s biggest supplier of mice and rats.

Researchers show that both mice and pigs are capable of oxygenating their blood via the colon—a capacity that, if shared by humans, could be leveraged in the clinic to minimize the need for mechanical ventilation.

A device that releases synthetic hormones slowly over time could one day provide a more practical alternative to daily birth control pills, say scientists.

The lab animals had more natural microbiomes seeded by wild mice, unlike conventional models that are kept in sterile conditions.

Some researchers and animal rights groups are amplifying their opposition to an assay that measures how long a rodent tries to stay afloat.

The California Institute for Regenerative Medicine has been funding research since it formed in 2004, giving out nearly $3 billion in grants to date.

Researchers boosted levels of the dystrophin protein to nearly normal levels in a canine model of the disease.

Applications for Phase 1 and 2 human studies in Germany frequently lack sufficient information about an intervention’s efficacy in animal experiments, according to a new study.  

Including as few as two labs in a study improved the odds of getting the true effect size by as much as 23 percentage points, according to a replication model.

The BMJ inquiry finds that researchers presented only select results from animal experiments when applying for funding and approval for human trials.

Mice receiving the treatment produced their own monoclonal antibodies and survived infection with the life-threatening pathogen Pseudomonas aeruginosa.

Neurons derived from human induced pluripotent stem cells fill in for lost dopamine neurons in a primate model of the disease.

Researchers overestimate the reliability of findings from animal studies that are part of the Reproducibility Project: Cancer Biology.

Animal experiments published in a handful of cardiovascular journals mostly ignore NIH guidelines.