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A 3D medical illustration of a human heart with a cardiogram in the foreground and a blue background that includes DNA helices.

Connecting the Complexities of Heart Failure and Aging

Deanna MacNeil, PhD | Feb 13, 2023 | 3 min read

Researchers learned how IGFBP7, a senescence signaling protein and biomarker, promotes cardiac remodeling and cellular aging.

a mouse moves away from the camera, its left leg caught in a cloth

Scientists Discover New “Superfast” Muscle Fibers in Mouse Limbs

Katherine Irving | Feb 9, 2023 | 4 min read

Fast twitch fibers like these could one day be used to treat diseases like Parkinson’s.

Metabolomic Links Between Environmental Exposures and Human Health

The Scientist’s Creative Services Team | 1 min read

Experts discuss how untargeted metabolomic studies connect environmental factors with human disease.

The face of a young woman and the face of an old man surrounded by mechanical clocks.

Daily Gene Expression Rhythms Vary with Sex and Age: Study

Alejandra Manjarrez, PhD | Feb 2, 2023 | 3 min read

By studying tissues from deceased people, a team found that women have more rhythmical gene expression and that this molecular rhythmicity decreases with age.

a centrifuge from a birds-eye view, spinning quickly with a colored blur

Scientists Use Centrifuge to Discover a Hormone

Katherine Irving | Jan 23, 2023 | 3 min read

A new method for isolating extracellular fluid aims to discover molecules with therapeutic potential that were previously obscured by highly abundant proteins.

Spatial Biology in Physiology and Pathology

The Scientist’s Creative Services Team | 1 min read

Elana Fertig and Sanjay Srivatsan discuss the importance of the spatial dimension for biological systems research.

A younger-looking mouse next to an older-looking one

Epigenetic Manipulations Can Accelerate or Reverse Aging in Mice

Alejandra Manjarrez, PhD | Jan 12, 2023 | 4 min read

Repairing damaged DNA appears to drive aging by causing the loss of epigenetic information, but restoring that information reverses such effects, a study finds.

Artist’s rendition of the molecular structure of a ribosome (blue and purple) as it produces a polypeptide chain (red) from an mRNA template (orange and gray), with tRNA molecules (dark purple) shuttling amino acids.

Specialized Sperm Ribosomes Are Key to Male Fertility in Mice

Dan Robitzski | Dec 15, 2022 | 4 min read

A previously unknown kind of ribosome is responsible for folding sperm proteins, which decay before fertilization if prepared by other ribosomes.

Demystifying the Black Box

The Scientist’s Creative Services Team and Tecan | 1 min read

One sophisticated laboratory tool detects absorbance, fluorescence, FRET, luminescence, live cells, and more, facilitating a wide variety of experimental findings.

A grayscale tomography image of snake tissue

Snakes Have Clitorises After All, Study Finds

Natalia Mesa, PhD | Dec 13, 2022 | 4 min read

Researchers visualize the snake clitoris in detail for the first time, finding evidence that the organ may be evolutionarily important for snake sex.

close-up photo of fruit fly on white background

Scientists ID Heart-Damaging SARS-CoV-2 Protein

Grace van Deelen | Nov 22, 2022 | 3 min read

In flies and mice, a viral protein increases the rate of energy use by heart cells. But it’s not yet clear if the finding applies to humans.

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Technique Talk: Redefining Mouse Transgenesis with CRISPR-Cas Technology

The Scientist’s Creative Services Team | 1 min read

Learn how CRISPR-Cas technology has revolutionized the creation of transgenic mouse models.

Turkey, mashed potatoes, stuffing, pumpkin pie and sides on a table

The Smell of Food Affects Metabolism in Fasting Mice

Shafaq Zia | Nov 18, 2022 | 3 min read

The odor prompted the animals’ fat cells to release lipids into circulation.

A mouse in front of an open sack of grain.

Mice Fed a Highly Processed Diet Are More Susceptible to the Flu

Alejandra Manjarrez, PhD | Nov 18, 2022 | 3 min read

It’s not clear why grain-fed mice are better able to recover after infection, but a study’s findings suggest food type may skew the results of animal studies.

Defined Primary Cell Culture and Media

The Scientist Creative Services Team in collaboration with MilliporeSigma | 3 min read

A new partnership opens the door for a source of highly purified human primary cells and defined cell culture media.

A nine-banded armadillo walking on dry grass.

Leprosy Bacterium Rejuvenates Armadillos’ Livers

Alejandra Manjarrez, PhD | Nov 15, 2022 | 4 min read

Mycobacterium leprae appeared to reprogram the animals’ livers to a state partially resembling early development, resulting in healthy organ growth.

Illustration showing immunology during pregnancy

Infographic: How Immunology Can Influence Pregnancy Outcomes

Tobias R. Kollmann, Arnaud Marchant, and Sing Sing Way | Nov 14, 2022 | 3 min read

Pregnancy-induced changes in the immune system are key to a successful birth. Understanding those changes could allow researchers to protect both mother and child.