molecular biology

Researchers turned to base editors to correct mutations causing the rare genetic disease Fanconi anemia without inducing double-strand DNA breaks.

The Scientist spoke with microbiologist William Whitman about a new system of nomenclature for prokaryotic organisms that can’t be cultured.

A technique for quantifying tumor mRNA production from messy tissue sample data uncovers an unexpected correlation between it and disease stage in 15 cancer types.

A study in mice finds that for certain genes, one parent’s allele can dominate expression and shape behavior—and which parent’s allele does so varies throughout the body.

The University of Washington researcher leveraged data from the Human Genome Project to identify genes underlying various health conditions and advance precision medicine.

He coined the term “structural biology.”

The International Committee on Systematics of Prokaryotes recently pulled the rank of phylum into its code of official nomenclature. Experts say the move will help standardize science in the long run but potentially disrupt research now.

Conservation of structures and functions between single-celled fungi and human cells allow researchers to probe the brain.

The single-celled fungus allows researchers to study Alzheimer’s, Parkinson’s, ALS and other brain diseases with unparalleled speed and scale.

Activation of retrotransposons in the animals’ cancerous cells sets off an innate immune response that triggers cell death.

The dynamic behavior of a transcriptional activator can be used to specify the activity level of its target gene, a study suggests.

The methodology involves modifying histones and displaying them on the cell surface for analysis.

By harnessing a unique property of yeast, scientists can synthesize histones and the enzymes that modify these proteins, which spool DNA and influence gene expression.