macrophage

Scientists studying pathogens such as Chlamydia, Legionella, and Listeria get a master class in how to control the internal workings of mammalian cells.

Various microbes, including several human pathogens, hijack the cell’s skeleton, membranes, and protein-making machinery to make themselves at home.

Whether the finding of a novel mechanism for cancer-related pain can lead to better treatments for neuropathic pain in people remains to be seen.

Research traces the evolution of a gene variant that reduces the risk of Alzheimer’s disease, finding that it originally evolved in response to infectious bacteria.

In Salmonella, two seemingly similar antibiotic survival strategies result from very different molecular mechanisms.

The continuous network of fluid-filled compartments crosses organ barriers and might serve as a conduit for tumor cells to spread.

Researchers turned white blood cells called neutrophils into drug-smuggling “neutrobots,” which penetrated the blood-brain barrier to treat brain cancer in mice.

Following on the success of CAR T cells used to treat cancers of the blood, researchers have launched a Phase 1 clinical trial of genetically modified macrophages to target solid tumors.

Researchers find different distributions of the immune cells in young, older, and diseased eyes.

Imaged in real time in living people, immune cells at the surface of the retina could serve as biomarkers to detect retinal and possibly neurological diseases and track their progression.

Knocking out the receptor for a lipid that causes inflammation rejuvenates macrophage metabolism and restores cognitive function in an Alzheimer’s disease model.

Excess of the inflammatory molecule bradykinin may explain the fluid build-up in the lungs of patients with coronavirus infections. Clinical trials of inhibitors are putting this hypothesis to the test.

The leaky blood vessels and lung fluid build-up in some COVID-19 patients might be explained by the virus’s corruption of an inflammation safeguard.

Studies are underway to test whether giving a shot of BCG vaccine could protect doctors and nurses against COVID-19.

Without a brain, the frog embryo immune system doesn’t receive the signals it needs to mobilize macrophages and fight infections.

The immunotherapy induces a form of cell death in leukemia cells in mice that triggers cytokine release syndrome, a dangerous inflammatory reaction that occurs in some patients.

The energy-producing organelles also send out parcels with antimicrobial compounds to help destroy pathogen invaders in macrophages.

Macrophages play numerous roles within tumors, leaving cancer researchers with a choice: eliminate the cells or recruit them.