longevity

Aging cells with weakened gene regulation spuriously transcribe RNAs, but their impact on health and longevity still needs to be examined.

By analyzing the genomes of 23 remarkably long-lived fish species, a study found two metabolic pathways associated with longevity.

Researchers say there may be similar, human genes whose effects on lifespan vary by sex.

Fasting, eating only at certain times of day, and restricting overall calorie intake can collectively contribute to lifespan extensions in animals. Could the same hold true in humans?

Increasing mitochondrial activity in worms by engineering a light-activated proton pump into the organelle’s membrane extends the animals’ lifespan without evidence of health decline, according to a preprint.

Activation of retrotransposons in the animals’ cancerous cells sets off an innate immune response that triggers cell death.

Worms, flies, and yeast live longer if the fidelity of their protein-making machinery is improved, a study shows.

Genes related to the immune system stay active throughout the tree’s life.

Suppressing the natural age-related increase in neuronal excitation lengthens the lives of worms, and there are indications that the same may be true for mice and humans.

The science isn’t there yet, nor are the known interventions that ought to be combined with delivering such predictions.

Worms with the reproduction-related TCER-1 gene deleted could fight off infection for longer and survived better when exposed to heat and radiation.

Those with two copies of the Δ32 allele in the CCR5 gene are 21 percent more likely to die by age 76, although it’s not clear why.

A neurologist by training, Stefánsson founded Iceland-based deCODE Genetics to explore what the human genome can tell us about disease and our species’ evolution.

A demographer’s model suggests the “mortality plateau” in the extreme elderly could be explained by clerical errors. Not everyone agrees.

The researchers say that their results are evidence we haven’t yet reached a limit to human lifespan.

Two studies examining the effects of parents’ ages on their offsprings’ telomere lengths come to opposite conclusions.  

Crowdsourced data from Geni.com, which includes the actor Kevin Bacon, answers questions about marriage, migration, and more.

From extending lifespan to bolstering the immune system, the drug’s effects are only just beginning to be understood.

Researchers find that while bats in the Myotis genus don’t produce telomerase, the enzyme that lengthens telomeres, they possess 21 telomere maintenance–related genes.