knockout mice

Disturbing circadian rhythms in organoids and mice increases intestinal tumor growth, findings that may explain a recent rise in colon cancer among young adults, the researchers behind the work say.

A study reveals a connection between the loss of enzymes responsible for removing methyl groups from DNA, nucleic acid knots, and cancer development in mice.

Independently produced knockout mouse strains fail to find evidence of the bone protein’s endocrine functions, and divide researchers’ opinions.

Researchers from 17 labs report low efficacy rates for the popular technique.

By removing a single gene, researchers change the developmental fate of tumor cells in mice.  

The Nobel laureate and Lasker awardee developed tools that facilitated decades of genetics research, including starch gel electrophoresis and gene targeting.

Researchers have identified a mutation in a commonly used commercial mouse strain that could impact experimental results.

Two drugs targeting a protein in sperm cause reversible infertility in male mice, providing new hope for a male contraceptive.

Some genetically engineered mice harbor unwanted mutations that hitchhike alongside desired modifications, affecting experimental outcomes.

Researchers identify a protein linked to excessive consumption of alcohol in animal models.

Researchers have created a line of model mice that naturally express Cas9, paving the way for rapid precision gene-editing.

Researchers find a new gene connected to obesity in a surprising part of the genome.

Is DNA damage an inevitable consequence of epigenetic reprogramming?