immunosuppression

Adeno-associated viral vectors can deliver gene therapies, but AAV-neutralizing antibodies might prevent the medicines from working.

Two studies present biological evidence that measles infections in unvaccinated children wipe out immune memories of other pathogens, putting the kids at risk of other deadly diseases.

The discovery suggests that the immune checkpoint can operate at a further distance from tumor cells than previously believed.

Boosting levels of a the immunosuppressive protein PD-L1 in blood stem cells halts diabetes in a mouse model of the disease.

A new study uses blood samples from pregnant women to track changes in the immune system leading up to birth, and predicts gestational age from the mothers’ immune signatures.

Two drugs targeting a protein in sperm cause reversible infertility in male mice, providing new hope for a male contraceptive.

Adult sickle-cell patients have safely stopped taking their immunosuppressant medication thanks to a new type of blood stem-cell transplant.

Drug-resistant immune cells protect patients from graft-versus-host disease after bone marrow transplant.

A new method for transplanting immunologically mismatched organs may remove the need for life-long immunosuppressive drugs to prevent rejection.