Human Genome Project

Thirty years out from the start of the Human Genome Project, researchers have finally finished sequencing the full 3 billion bases of a person’s genetic code. But even a complete reference genome has its shortcomings.

The University of Washington researcher leveraged data from the Human Genome Project to identify genes underlying various health conditions and advance precision medicine.

Caskey’s contributions to the field were instrumental to modern genetics.

Collins has announced his intent to step down after leading the National Institutes of Health for more than 12 years.

In a preprint, researchers fill in some of the holes left in the first draft of the human genetic code, published at the turn of the century.

A new analysis of 1,000 Swedes uncovers a chromosome’s worth of novel DNA sequences—much of them ancient—underscoring the need for a more diverse reference genome.

Researchers must ensure that the inequality seen in most of today’s genomic studies and databases is corrected.

The biologist earned a Nobel Prize in 2002 for his work on C. elegans.

A proposal to synthesize entire genomes—the subject of a controversial, invitation-only meeting at Harvard last month—is formally presented in Science.

A closed-door gathering at Harvard last week hosted researchers talking about synthesizing entire genomes, including that of humans. 

Fifteen years after publication of the human genome’s first draft sequence, what has become of the hundreds of researchers who worked on the project?

A massive screen yields the most comprehensive map of binary human protein interactions to date.

Proteomic data suggest the human genome may encode fewer than 20,000 genes.

What researchers are learning as they sequence, map, and decode species’ genomes

From research results to electronic health records, biomedical data are becoming increasingly accessible. How can scientists best capitalize on the information deluge?

Scientists present the first major human genome assembly update since 2009.

A new analysis suggests that the Human Genome Project has delivered $178 for every federal dollar invested, but many analysts are not convinced by the figures.

Was the Human Genome Project the key to a gold mine?

First, Aravinda Chakravarti drew a map of how scientists might unravel the genetics of complex disease. Then he blazed the trail.