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Overcoming Cancer Therapy Obstacles With Epitope Editing
Overcoming Cancer Therapy Obstacles With Epitope Editing
Editing epitopes expressed on the surfaces of transplanted hematopoietic stem cells renders them resistant to AML treatments without affecting their critical functions.
Editing epitopes expressed on the surfaces of transplanted hematopoietic stem cells renders them resistant to AML treatments without affecting their critical functions.
hematopoietic stem cells
Unlocking the Secrets within Cells Using Next Generation Sequencing
The Scientist’s Creative Services Team | Sep 25, 2023 | 1 min read
Next generation sequencing (NGS) core facility scientists and researchers discuss their latest work exploring novel cancer models and stem cells in space.
How Can Core Labs Help You Get Started with NGS?
The Scientist’s Creative Services Team | Aug 9, 2023 | 1 min read
Next-generation sequencing (NGS) core facility scientists and researchers new to NGS discuss their fruitful collaborations, highlighting how to receive expert help from genomics facilities.
Hematopoietic Stem Cells and Their Role in Development and Disease Therapy
Jennifer Zieba, PhD | Aug 24, 2022 | 5 min read
Hematopietic stem cells (HSCs) are multipotent cells found in the blood and bone marrow with the ability to self-renew and differentiate into multiple cell types during bone marrow hematopoiesis
LabTalk Podcast - Hijacking Genes: Uncovering the Cause of Lineage Ambiguous Leukemia
The Scientist’s Creative Services Team | Oct 28, 2021 | 1 min read
Chromosomal rearrangements reposition influential and often overlooked non-coding elements in the genome to hijack genes and cause cancer.
The MSC: Regeneration Orchestrator
The Scientist Staff | Nov 16, 2020 | 7 min read
Scientists uncover the promise of mesenchymal stem cells (MSCs), also known as medicinal signaling cells, to modulate the immune system and regenerate tissue.
Multiomic Single-Cell Analysis Identifies a Unique Stem and Progenitor Population
The Scientist’s Creative Services Team | Jul 14, 2020 | 2 min read
Margaret Nakamoto will introduce the BD Rhapsody™ Single-Cell Analysis System, and Ravi Majeti will discuss how he and his team used concurrent RNA and BD® AbSeq Antibody-oligo multiplexed surface marker analysis to improve HSPC clustering and characterize specific phenotypic states along unique hematopoietic differentiation trajectories.
Northwestern University Stem Cell Therapy Clinic Closes Abruptly
Katarina Zimmer | Sep 6, 2019 | 5 min read
A Chicago-based center that has long operated a clinical trial program for stem cell therapies, has stopped recruiting further patients as its chief, Richard Burt, leaves for a research sabbatical.
Image of the Day: Powerful Protein
Chia-Yi Hou | Apr 25, 2019 | 1 min read
An experiment tests whether a protein treatment can help hematopoietic stem cells recover after mice are exposed to radiation.
Alcohol Damages Mouse DNA
Jef Akst | Jan 3, 2018 | 1 min read
A byproduct of alcohol consumption causes mutations in the DNA of mouse blood stem cells, and some of the breaks are not repaired.
Top Technical Advances in 2017
Shawna Williams | Dec 24, 2017 | 3 min read
The year’s most impressive achievements include new methods to extend CRISPR editing, patch-clamp neurons hands-free, and analyze the contents of live cells.
Vitamin C Depletion Accelerates Leukemia in Mice
Aggie Mika | Aug 21, 2017 | 2 min read
High levels of vitamin C absorbed by blood-forming stem cells are important for their normal development.
Vitamin C Blocks Leukemia Progression in Mice
Aggie Mika | Aug 17, 2017 | 3 min read
High-dose vitamin C injections reverse the effects of a leukemia-promoting genetic deficiency.
Blood Stem Cells Grown in the Lab
Ashley Yeager | May 17, 2017 | 3 min read
Researchers identify transcription factors and environmental conditions necessary to reprogram human and mouse cells into cells that function like hematopoietic stem cells.
Synthetic Bones: A Better Bone-Marrow Transplant?
Ashley P. Taylor | May 9, 2017 | 2 min read
Artificial bones produce new blood cells in mice, obviating the need for irradiation to kill off resident hematopoietic stem cells in recipients.
How to Track Cell Lineages As They Develop
Kelly Rae Chi | Dec 1, 2016 | 7 min read
Sequencing and gene-editing advances make tracing a cell’s journey throughout development easier than ever.
More Success Fixing Sickle Cell Gene with CRISPR
Kerry Grens | Nov 9, 2016 | 1 min read
Researchers say they have sufficient in vitro and animal data to apply for human testing.
TS Picks: August 9, 2016
Bob Grant | Aug 9, 2016 | 2 min read
Gene therapy money-back guarantee; the brain benefits from bilingualism; Q&A with a science watchdog