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Graphical heart and heartbeat
Connecting the Complexities of Heart Failure and Aging
Researchers learned how IGFBP7, a senescence signaling protein and biomarker, promotes cardiac remodeling and cellular aging.
Connecting the Complexities of Heart Failure and Aging
Connecting the Complexities of Heart Failure and Aging

Researchers learned how IGFBP7, a senescence signaling protein and biomarker, promotes cardiac remodeling and cellular aging.

Researchers learned how IGFBP7, a senescence signaling protein and biomarker, promotes cardiac remodeling and cellular aging.

heart failure

knitted pink heart with a mended hole
CAR T Cells Mend Broken Mouse Hearts
Sophie Fessl, PhD | Jan 6, 2022 | 4 min read
Specialized immune cells generated in vivo reduce cardiac scar tissue in mice, a new study shows.
Pig Hearts Provide Long-Term Cardiac Function in Baboons
Ruth Williams | Dec 5, 2018 | 3 min read
Primates receiving heart transplants from genetically engineered pigs have survived more than six months, a new study reveals.
First iPS Cell Trial for Heart Disease Raises Excitement, Concern
Katarina Zimmer | Aug 31, 2018 | 4 min read
Without knowing the cells’ mechanism of action, researchers question the best way to administer them to patients.
Cardiac Cell Transplants Help Monkeys’ Hearts
Ashley Yeager | Jul 2, 2018 | 2 min read
The organ’s blood-pumping capacity improved with the infusion of cells, a study shows.
Why Afternoon Open Heart Surgery Is Better for Patient Outcomes
Catherine Offord | Oct 27, 2017 | 2 min read
Research in human patients and mice reveals the role of the circadian clock in the risk of heart damage at different times of day.
Image of the Day: Un-break My Heart
The Scientist Staff | Aug 8, 2017 | 1 min read
A failing heart is easily distinguished from a healthy one by numerous tell-tale signs, including its slender, stretched-out walls, increased size, and pooled blood clots.
Heart’s Backup Pacemaker Mechanisms Identified
Diana Kwon | Jul 28, 2017 | 2 min read
The sinoatrial node is home to multiple pacemakers that keep the heart beating if the main one falters.
In Failing Hearts, Cardiomyocytes Alter Metabolism
Amanda B. Keener | Jun 1, 2016 | 2 min read
While the heart cells normally burn fatty acids, when things go wrong ketones become the preferred fuel source.
The Fatty Acid–Ketone Switch
Amanda B. Keener | May 31, 2016 | 1 min read
In failing hearts, cardiomyocytes change their fuel preference.
If It Ain't Broke . . .
Kerry Grens | Jan 1, 2016 | 4 min read
Is there room to improve upon the tried-and-true, decades-old technology of artificial hearts?
Hearts in Hand
The Scientist Staff | Dec 31, 2015 | 1 min read
Texas Heart Institute heart surgeon Bud Frazier is a pioneer of heart transplant technologies.
Cell Transplants for Heart Questioned
Jef Akst | May 1, 2014 | 2 min read
A report reveals that using bone marrow stem cells to treat heart disease is less promising than a decade of research has let on.
Saving Failing Hearts
Kate Yandell | Mar 12, 2014 | 4 min read
Inhibiting a small regulatory RNA appears to improve cardiac function in mice with surgically induced heart problems.
Next Generation: Sensor-Laden Sheath to Monitor the Heart
Daniel Cossins | Feb 25, 2014 | 3 min read
A flexible, sensor-loaded membrane that fits snugly around the heart provides high-resolution monitoring of multiple cardiac health markers.
More Questionable Stem-Cell Science
Chris Palmer | Jun 18, 2013 | 2 min read
Disgraced stem-cell researcher Hisashi Moriguchi has published three new papers in BMJ Case Reports, including a rehashing of a retracted 2012 paper.
Blood Protein Rejuvenates Aging Heart
Dan Cossins | May 10, 2013 | 2 min read
A molecule found only in the blood of young mice dramatically reverses thickening and stiffening of the heart muscle in old mice.
Opinion: An Explosion of Devices
Stephen C. Schimpff | Jan 28, 2013 | 3 min read
From cardiovascular problems to neurological disorders, a plethora of new medical devices are reducing the need for surgery and improving the quality and safety of healthcare.
New Biological Pacemaker
Dan Cossins | Dec 18, 2012 | 1 min read
In guinea pigs, the insertion of a single gene can transform ordinary heart cells into pacemaker cells that regulate cardiac rhythm.
Omega-3s: Fishing for a Mechanism
Ethan J. Anderson and David A. Taylor | Nov 1, 2012 | 10+ min read
Despite abundant evidence supporting their ability to help prevent and treat cardiovascular disease, the therapeutic effectiveness of fish oil–derived fatty acids remains controversial.
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