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genetics

Patient with skin blisters being swabbed by gloved hand
Delivering Gene Therapies in Utero 
Natalia Mesa, PhD | Jul 18, 2023 | 3 min read
By delivering mRNA to the skin of mice in utero, researchers showed a proof-of-concept for shuttling gene therapies to skin cells before birth.
Photo of Rosa Bacchetta, associate professor of pediatrics at Stanford University
The Future of Gene Therapy for a Rare Pediatric Autoimmune Disease
Niki Spahich, PhD | Jul 10, 2023 | 3 min read
By editing a mutated immune regulatory gene in patient cells, Rosa Bacchetta brings hope to those suffering from IPEX syndrome.
David Liu
Targeting a Genetic Accident to Treat Disease
Deanna MacNeil, PhD | 2 min read
David Liu shares how integrating chemistry and evolution in his research has directed his work on base editing techniques aimed at developing new therapeutics.
Chromosome with gold band
Immunity Genes May Play a Role in Down Syndrome
Kamal Nahas, PhD | Jul 6, 2023 | 4 min read
Extra copies of four interferon receptor genes found on human chromosome 21 trigger developmental changes in a mouse model of Down syndrome.
Image of in vitro fertilization
Should the scientific community abandon the 14-day rule for research on human embryos?
Ida Emilie Steinmark, PhD | Jul 5, 2023 | 2 min read
Research on human embryos is usually limited to the first 14 days of development, but as scientific capabilities improve, some argue that it is time to go further.
Test tubes containing liquid biopsy samples with circulating tumor DNA (ctDNA)
Supporting the Evolution of Liquid Biopsies
The Scientist Creative Services Team in collaboration with Twist Bioscience | 1 min read
Sequencing circulating tumor DNA (ctDNA) within liquid biopsies permits tumor identification and tracking. 
Puzzle icon
Using Multiple Techniques for Gene Expression Analysis
The Scientist Staff | Jul 5, 2023 | 2 min read
A single approach rarely addresses all research needs. Learn when and how to employ sequencing and PCR-based methods.
Cheese wheels with moldy rinds on a wooden plank
Deleting a Gene Quells a Pesky Cheese-Destroying Fungus
Natalia Mesa, PhD | Jun 30, 2023 | 3 min read
Fungi disrupt microbial communities on cheese by making antibiotics. 
Thermo
Molecular Diagnostics: An Eye Toward the Future
The Scientist’s Creative Services Team and Thermo Fisher Scientific | 2 min read
Scientists discuss their successes and challenges when creating new assays for molecular diagnostics.
Glowing red DNA on bluish background
Redesigning Medicine Using Synthetic Biology
Alison Halliday, PhD, Technology Networks | Jun 21, 2023 | 5 min read
Drawing inspiration from nature, synthetic biology offers exciting opportunities to transform the future of medicine.
Woman with her back to camera, with arms stretched out, soaking up the sunshine
A Genetic Predisposition to Vitamin D Deficiency Contributes to Severe COVID-19
Iris Kulbatski, PhD | Jun 1, 2023 | 3 min read
Ana Teresa Freitas discussed how individual variation in vitamin D synthesis and metabolism influences susceptibility to upper respiratory viruses.
Layered visual representation of multiomics
Integrate and Innovate with NGS and Multiomics
The Scientist’s Creative Services Team and Illumina | 6 min read
Researchers across disciplines combine layers of discovery obtained with accessible NGS-based multiomics approaches.
Sir Richard Roberts won the 1993 Nobel Prize “for their discoveries of split genes.” 
How Restriction Enzymes Changed Biology
Nathan Ni, PhD | Jun 1, 2023 | 4 min read
Endonuclease R changed Richard Roberts’ career trajectory and created an industry.
mosquito on leaf
Combating Mosquito-Borne Diseases with CRISPR
Niki Spahich, PhD | Jun 1, 2023 | 4 min read
As alternatives to insecticides, Omar Akbari uses sophisticated genetic engineering methods to solve the world’s mosquito problems.
PCR setup thumbnail
Important Players for a Successful PCR
The Scientist’s Creative Services Team and MilliporeSigma | 1 min read
Learn about other PCR components—beyond the polymerase—that are essential for optimal results.
Doug Hanahan worked at Cold Spring Harbor Laboratory in 1982. 
Cellular Competence: Making Recombinant DNA Accessible
Nathan Ni, PhD | Jun 1, 2023 | 2 min read
Coaxing bacteria into taking up recombinant DNA was arduous until Douglas Hanahan took action.
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
Single Cell Sequencing in a Nutshell
Single Cell Sequencing in a Nutshell
Niki Spahich, PhD | 4 min read
By exploring the inner workings of individual cells, rather than averaging bulk populations, researchers identify rare and important cell subtypes.
Editing genome stock photo
Resolving Discrepancies in Mouse and Human Autoimmunity Studies
Niki Spahich, PhD | May 15, 2023 | 4 min read
By editing primary T cells with CRISPR, researchers begin to settle a long-standing debate about a common autoimmunity risk variant.
Medical illustration of a scientist replacing part of a DNA molecule with tweezers, representing genome editing.
On the Hunt for the Next Breakthrough in Motor Neuron Disease
Deanna MacNeil, PhD | May 9, 2023 | 3 min read
Researchers leave no stone unturned in the search for a spinal muscular atrophy treatment strategy that uses base editing.
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