drug development

A study finds that engineered exosomes are effective in mice, but their potential use in humans raises safety questions.  

As the new agency’s director, the DARPA veteran will spearhead a high-risk, high-reward approach to biomedical research.

The group’s 7-2 ruling in favor of the therapeutic represents a shift from previous deliberations, in which data on its effectiveness was deemed insufficient.

Launched with a $172 million philanthropic donation and funds from the state of Victoria, the Melbourne-based research institute aims to construct drug discovery platforms to speed the introduction of new therapies.

The Medicines and Healthcare products Regulatory Agency’s investigation comes after a study showed prenatal exposure to topiramate roughly triples a child’s likelihood of having autism or intellectual disability.

A review by the US Office of Inspector General found that only about half of the scientists running clinical trials funded by the NIH in 2019 and 2020 appropriately recorded their findings in a federal database, as is legally required.

No deaths had previously been associated with the muscle-wasting treatment Zolgensma.

Mixtures of viruses that attack inflammatory bowel disease–causing bacteria in mice also survive the digestive tract and are well-tolerated in humans, a study finds.

A lack of comprehension among some researchers about how to use ClinicalTrials.gov may be hindering public access to trial information and holding up drug study results, an investigation by The Scientist finds.

A large trial adds to a growing list of conditions once thought to be helped by vitamin D supplementation.

Agency members express hope that the availability of a traditional, protein-based vaccine might convince holdouts to get vaccinated.

The biotech company Verve Therapeutics launched the study with the aim of using base editing to treat a genetic condition that causes high cholesterol and increases a person's risk of developing cardiovascular disease.

IgA antibodies appear to bind to specific species of commensal gut bacteria in mice, according to a study.

The shift is likely to add to an ongoing shortage of primates used in labs, which could slow progress in future COVID-19 vaccine development and other areas.