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Image shows photorhabdus virulence cassettes (green) binding to insect cells (blue) prior to injection of payload proteins. 
Engineered Bacterial “Syringes” Can Deliver Drugs Into Human Cells
Researchers repurpose tiny bacterial injection systems to specifically inject a wide variety of proteins into human cells and living mice.
Engineered Bacterial “Syringes” Can Deliver Drugs Into Human Cells
Engineered Bacterial “Syringes” Can Deliver Drugs Into Human Cells

Researchers repurpose tiny bacterial injection systems to specifically inject a wide variety of proteins into human cells and living mice.

Researchers repurpose tiny bacterial injection systems to specifically inject a wide variety of proteins into human cells and living mice.

drug delivery

Structure of a Chlamydomonas, green algae
Drugs Hitch a Ride on Algae for Targeted Delivery
Holly Barker, PhD | Feb 1, 2023 | 3 min read
A new microrobot uses algae to transport antibiotics into the lungs of mice with pneumonia.
Illustration showing microscopic algae swim through mouse lungs and deliver nanoparticles of an antibiotic attached to their surfaces
Infographic: Algae Robots Transport Antibiotics to Infected Tissues
Holly Barker, PhD | Feb 1, 2023 | 1 min read
Microscopic algae dotted with drug-filled nanoparticles may offer a more effective means of treatment than traditional delivery methods.
Building a Synthetic Biology Platform for Drug Delivery
Building a Synthetic Biology Platform for Drug Delivery
The Scientist’s Creative Services Team | 1 min read
Kate Adamala and Niren Murthy will discuss the latest advances in drug delivery using synthetic biology approaches.
Lipid nanoparticle delivers treatment to a cancer cell.
Researchers Develop a CRISPR-Based Therapy That Penetrates Solid Tumors
Jennifer Zieba, PhD | Oct 10, 2022 | 3 min read
By packaging lipid nanoparticles with elements that decrease the fibrous nature of solid tumors, researchers can deliver CRISPR therapies in a more efficient manner.
A germinal center inside a lymph node
Slow Vaccine Delivery May Maximize Immune Response
Alejandra Manjarrez, PhD | Sep 23, 2022 | 5 min read
A vaccine strategy involving formulation changes, an initial escalating dose, and a longer wait for booster immunization results in more-effective antibody production against HIV in rhesus monkeys, a study finds.
Linking Biological Clocks and Cancer Therapeutics to Minimize Toxicity
It’s All in the Timing: Optimizing Chemotherapy Administration
Sejal Davla, PhD | 1 min read
How the biological clock influences chemotherapy success
A microneedle patch on a fingertip
Opinion: An Alternative to Injection
Carmine D’Amico and Hélder Santos | Sep 9, 2021 | 3 min read
Research on microneedle patches for vaccine delivery has grown in popularity in recent years, due to their exceptional compliance and low invasiveness.
Red blood vessels that decrease in diameter as they radiate outward are pictured on a pink and white surface
Antisense Oligonucleotides Cross Rodents’ Blood-Brain Barrier
Abby Olena, PhD | Aug 18, 2021 | 3 min read
RNA-DNA complexes that were modified with cholesterol made it into the brains of rats and mice, where they knocked down target genes.
Harnessing microRNAs for Cancer Therapeutics
Harnessing microRNAs for Cancer Therapeutics
The Scientist’s Creative Services Team | 1 min read
Andrea Kasinski and Masako Harada will discuss the role of microRNAs in cancer, as well as the potential and challenges of using microRNAs for cancer therapeutics.
Questions Raised About Widely Used Blood-Brain Barrier Model
Catherine Offord | Feb 16, 2021 | 6 min read
A study has sparked controversy by suggesting that cells made using a popular lab protocol have been misidentified, with potentially serious repercussions for brain research. Critics say the significance of the findings has been overstated.
Infographic: Building Bacteria to Fight Cancer
Simone Schuerle and Tal Danino | Apr 1, 2020 | 3 min read
Researchers are engineering microbes to deliver therapeutics specifically to tumors, maximizing the treatments’ efficacy while minimizing side effects.
Bacteria as Living Microrobots to Fight Cancer
Simone Schuerle and Tal Danino | Apr 1, 2020 | 10+ min read
Autonomous, living microrobots that seek and destroy cancer are not as futuristic as one might imagine, thanks to a fusion of robotics and synthetic biology.
Laser-Triggered Nanobubbles Blast a Path into Biofilms
Jonathan Wosen | Apr 1, 2020 | 4 min read
Researchers could one day use the method to deliver antibiotics to topical wounds infected by hard-to-treat masses of bacteria.
CRISPR-Based Tool Expands DNA-Hydrogel Versatility
Ruth Williams | Dec 1, 2019 | 3 min read
DNA-responsive polymer gels used for releasing drugs, encapsulating cells, and much more now have greater adaptability thanks to the Cas12a nuclease.
Trial of Gene Therapy for Duchenne Muscular Dystrophy Put on Hold
Catherine Offord | Nov 12, 2019 | 2 min read
The US Food and Drug Administration halts a study by Solid Biosciences after a patient experiences severe side effects following treatment.
smartphone controlled device implanted in mouse brain
Image of the Day: Smartphone-Controlled Brains
Nicoletta Lanese | Aug 7, 2019 | 1 min read
A device implanted into mice can modulate brain circuit activity over long periods of time.
Microneedle patch delivers liquid medications
Image of the Day: Artificial Snake Bite
Nicoletta Lanese | Aug 6, 2019 | 1 min read
A microneedle delivers liquid medicines through tiny, fang-like points.
Hydrogel injected near tumors help recruit cancer drugs to the site
Image of the Day: Right on Target
Nicoletta Lanese | Jul 23, 2019 | 1 min read
An injectable biomaterial calls cancer drugs to tumor sites in mice.
World’s Largest Cell and Gene Therapy Plant Opens
Catherine Offord | Apr 10, 2018 | 1 min read
Lonza will employ more than 200 full-time staff to work at the Texas-based facility, the company says.
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