DNA sequencing

Researchers turn to high resolution sequencing to explain recurrent melanoma mutations caused by UV exposure.

Where and how human papillomavirus integrates itself into the human genome steers the infection’s clinical outcomes, finds a large, multifaceted study.

A high-quality reference genome for this vulnerable feline may help scientists understand why they’re so prone to transitional cell carcinoma in captivity.

This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.

Most differences in gene expression among cells within a tumor are likely due to environment or noise, a study suggests. 

With ever-advancing genetic technologies, researchers continue to document the genetic code of the human species.

Thirty years out from the start of the Human Genome Project, researchers have finally finished sequencing the full 3 billion bases of a person’s genetic code. But even a complete reference genome has its shortcomings.

Genetic studies have made it clear that eukaryotic horizontal gene transfer can and does happen. Exactly how, though, remains speculative.

DNA passed to and from all kinds of organisms, even across kingdoms, has helped shape the tree of life, to a large and undisputed degree in microbes and also unexpectedly in multicellular fungi, plants, and animals.

Analyzing the whole genome sequences of more than 18,000 tumors, researchers catalog nearly 60 new patterns of mutations that could inform cancer treatment.

In a preprint, researchers fill in some of the holes left in the first draft of the human genetic code, published at the turn of the century.

A founder of the field of synthetic biology is selling data from his own DNA as a nonfungible token, or NFT, through Nebula Genomics, a personal genome company he cofounded.

Sykes sequenced famous ancient remains, such as Ötzi and Cheddar Man, and was one of the first researchers to use mitochondrial DNA to trace genetic lineages.