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Explore protein structure-function relationships with Site Saturation Variant Libraries

Improved Protein Engineering with a Synthetic Variant Library

Researchers use a directly-synthesized, near-complete variant library to avoid the limitations of error-prone PCR.

Improved Protein Engineering with a Synthetic Variant Library

Improved Protein Engineering with a Synthetic Variant Library

Researchers use a directly-synthesized, near-complete variant library to avoid the limitations of error-prone PCR.

Researchers use a directly-synthesized, near-complete variant library to avoid the limitations of error-prone PCR.

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directed evolution

directed evolution

PCR tubes placed into the 96-well loading chamber of a PCR thermocycler instrument.

Directing Superior Reagents for Better PCR Results

The Scientist’s Creative Services Team and MilliporeSigma | Oct 2, 2023 | 3 min read

Directed evolution approaches are creating new reagents to help a tried-and-true technique reach new heights.

Directed Evolution, Phage Display Nab Chemistry Nobel

Catherine Offord and Kerry Grens | Oct 3, 2018 | 4 min read

The 2018 award goes to Frances Arnold, Gregory Winter, and George Smith.

Engineered Bacteria Build Carbon-Silicon Bonds

Joshua A. Krisch | Nov 28, 2016 | 1 min read

Researchers tweak bacterial proteins, turning them into powerful enzymes capable of producing silicon-carbon compounds naturally and more efficiently than manmade catalysts.

Reverse Transcriptase with Proofreading Capabilities Created

Alison F. Takemura | Jun 27, 2016 | 2 min read

Using directed evolution, researchers selected a DNA polymerase to copy RNA into DNA.

Chemical Engineer Wins Millennium Technology Prize

Tanya Lewis | May 25, 2016 | 1 min read

Caltech’s Frances Arnold is honored for her work on directed evolution.

Genes Get in Your Eye

Ruth Williams | Jun 12, 2013 | 3 min read

Directed evolution of a gene therapy virus vector improves its penetration into the retina.

Flies Evolve to Count

Hayley Dunning | Jul 12, 2012 | 1 min read

Researchers breed fruit flies that, after 40 generations of conditioning, have acquired the ability to react to numbers.

The Immune System as a Tool for Directed Evolution

Aileen Constans | Jan 30, 2005 | 3 min read

A team of researchers at the University of California, San Diego, has harnessed the body's ability to tweak antibody genes to drive protein evolution in the lab.

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