cystic fibrosis

Scientists engineered a lung-on-a-chip model from patient cells that mimics cystic fibrosis.

The treatment, Trikafta, increases lung function in most patients with the disease—but comes with a hefty price tag.

Tweaking the genomes of two phages and combining them with a third phage helped to clear a persistent Mycobacterium infection in the patient.

Certain populations have been historically underrepresented in genome sequencing studies, but the NIH, private clinics, and 23andMe and other companies are trying to fix that.

Inhalable particles carrying mRNA make mouse lungs glow.

The cell type was discovered via single-cell RNA sequencing of thousands of cells in mouse and human airways and may play a role in cystic fibrosis.

The results of a Phase 2 trial suggest that delivering normal copies of the gene that causes cystic fibrosis may slow lung decline.

What researchers are learning as they sequence, map, and decode species’ genomes

Although it’s far less populated than the mouth community that helps feed it, researchers increasingly appreciate the role of the lung microbiome in respiratory health.

The agency has cleared marketing of four next-generation sequencing devices from Illumina.

First, Aravinda Chakravarti drew a map of how scientists might unravel the genetics of complex disease. Then he blazed the trail.

The microbiome of the lung is different in patients with the disease, which causes a thick buildup of mucus that makes breathing difficult.

After a lightning-fast approval, the first medicine to treat an underlying cause of the disorder hits the market.

Scientists track changes in bacterial genomes during a hospital outbreak to discover potential pathogenesis genes.