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CRISPR

Image of <em >Candida albicans</em> fungus.

A Fungus Plays Tug-of-war for Metal Ions

Laura Tran, PhD | Sep 14, 2023 | 3 min read

In the fight between hosts and fungal pathogens, scientists discovered how withholding manganese can cripple Candida albicans.

This shows a cryo-EM map of a Fanzor protein in complex with its guiding RNA (in purple) and DNA (target strand in red, complementary strand in blue).

CRISPR-like Abilities in Eukaryotic Proteins

Ida Emilie Steinmark, PhD | Sep 8, 2023 | 4 min read

Two groups independently discovered that Fanzor proteins in eukaryotic organisms are CRISPR’s genome-editing cousins.

<em >The Scientist</em>’s Journal Club: Detecting Nucleic Acids with CRISPR

The Scientist’s Journal Club: Detecting Nucleic Acids with CRISPR

The Scientist’s Creative Services Team | 1 min read

Kuangwen Hsieh will discuss his research understanding CRISPR-based nucleic acid detection assays.

A dart board with on dart on the bullseye and several scattered darts that missed the target

Predicting the Next Level of CRISPR Control

Deanna MacNeil, PhD | Aug 28, 2023 | 3 min read

Scientists combine the power of genome-wide screens and machine learning to unlock the secrets of transcriptome engineering with Cas13.

Blood vessel with flowing red blood cells and white immune cells.

New CRISPR Treatment Could Prevent HIV Reinfection after Viral DNA Excision

Jennifer Zieba, PhD | Aug 21, 2023 | 3 min read

Researchers design dual CRISPR treatments to remove HIV DNA and prevent reinfection in vitro.

Targeting a Genetic Accident to Treat Disease

Deanna MacNeil, PhD | 2 min read

David Liu shares how integrating chemistry and evolution in his research has directed his work on base editing techniques aimed at developing new therapeutics.

A transverse section of stem wood from the researchers’ greenhouse-grown poplar tree.

CRISPR Trees Could Improve Paper Production

Alejandra Manjarrez, PhD | Aug 15, 2023 | 3 min read

Researchers edited several tree genes to improve suitability and sustainability in the pulp and paper industry.

Photo of Rosa Bacchetta, associate professor of pediatrics at Stanford University

The Future of Gene Therapy for a Rare Pediatric Autoimmune Disease

Niki Spahich, PhD | Jul 10, 2023 | 3 min read

By editing a mutated immune regulatory gene in patient cells, Rosa Bacchetta brings hope to those suffering from IPEX syndrome.

Versatile and Sustainable: Cell Counting for the 21^st Century

The Scientist’s Creative Services Team and DeNovix Inc. | 3 min read

Discover how the latest cell counting technology is reshaping a mundane task for the future.

Immunity Genes May Play a Role in Down Syndrome

Kamal Nahas, PhD | Jul 6, 2023 | 4 min read

Extra copies of four interferon receptor genes found on human chromosome 21 trigger developmental changes in a mouse model of Down syndrome.

Glow-in-the-dark Diagnostics

Danielle Gerhard, PhD | Jul 5, 2023 | 2 min read

A nucleic acid detection platform that marries CRISPR diagnostic tools with bioluminescence could accelerate treatment decisions in the clinic.

COVID-19: Lessons Learned

The Scientist’s Creative Services Team | 2 min read

An expert panel will discuss what researchers have learned from the COVID-19 pandemic and what lessons remain for the future.

Redesigning Medicine Using Synthetic Biology

Alison Halliday, PhD, Technology Networks | Jun 21, 2023 | 5 min read

Drawing inspiration from nature, synthetic biology offers exciting opportunities to transform the future of medicine.

Combating Mosquito-Borne Diseases with CRISPR

Niki Spahich, PhD | Jun 1, 2023 | 4 min read

As alternatives to insecticides, Omar Akbari uses sophisticated genetic engineering methods to solve the world’s mosquito problems.

3d render illustration of Single strand ribonucleic acid.

Message in a Bottle: Developing mRNA Therapeutics

The Scientist’s Creative Services Team and Mirus Bio | 3 min read

A high efficiency, low toxicity method for direct RNA delivery into cells.

Scientist pipetting at the bench in white coat and purple gloves

Chek-Mate for Gliomas

Aparna Nathan, PhD | May 22, 2023 | 3 min read

New research may make immunotherapy possible for hard-to-treat brain tumors.

Researchers in George Church’s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.

A Pioneer of The Multiplex Frontier

Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read

George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.