cancer therapeutics

Researchers investigated how cancer antigenicity drives unique forms of T cell exhaustion and hypofunctionality.

Colonizing tumors with engineered bacteria may allow researchers to target sites currently inaccessible to radionuclide therapy.

The extent to which transcription is higher in tumor cells than in surrounding nontumor cells is associated with bad prognoses in several cancer types.

Most differences in gene expression among cells within a tumor are likely due to environment or noise, a study suggests. 

A study finds that engineered exosomes are effective in mice, but their potential use in humans raises safety questions.  

A study reveals a molecular pathway linking exercise to an amped-up immune response to pancreatic cancer and greater responsiveness to treatment.

Self-inflicted DNA breaks let the cells hit pause on repair of radiation-induced DNA damage, giving them time to recover, an in vitro study shows.

Because most people are vaccinated against tetanus as children, delivering benign bacteria carrying a tetanus antigen into pancreatic tumors makes them visible to memory cells in the immune system, researchers report.

Unsatisfied by how treatments for childhood leukemia failed to prevent the disease’s return, Pinkel combined them all—and virtually cured the disease.

The immune cells facilitate healing, but they may also help tumors metastasize to the lungs after injury, a study in mice finds.

When coated with positively charged particles, the bacteria shuttled antigens out of tumors and activated the immune system, a study finds.

Data from mouse models for mild coronavirus infections and human tissue samples offer further evidence that it doesn’t take a severe infection—or even infection of brain cells at all—to cause long-term neurological symptoms.

Specialized immune cells generated in vivo reduce cardiac scar tissue in mice, a new study shows.