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Multiple Targets, Infinite Possibilities
Multiple Targets, Infinite Possibilities
Multispecific antibodies are rising stars in the field of antibody therapeutics, offering better specificity, targeting ability, and therapeutic effects than traditional monoclonal antibodies.
Multispecific antibodies are rising stars in the field of antibody therapeutics, offering better specificity, targeting ability, and therapeutic effects than traditional monoclonal antibodies.
antigens
Translation of “Jumping Genes” Creates Cancer Therapy Targets
Natalia Mesa, PhD | Mar 29, 2023 | 4 min read
Researchers find many tumor-specific antigens form when cancer genes and transposable elements link up.
Jumping Genes Put a Target on Cancerous Cells
Natalia Mesa, PhD | Feb 14, 2023 | 4 min read
Two studies find that tumor-specific antigens are often peptides that result from a splicing event between exons and transposable elements.
Understanding Hybridoma Technology for Monoclonal Antibody Production
Alpana Mohta, MD | 5 min read
By fusing antibody-producing cells with immortal myeloma cells, researchers produce reliable supplies of highly specific antibodies.
Targeting Antigen “Sanctuary” in Lymph Nodes Could Make Vaccines Better
Natalia Mesa, PhD | Feb 10, 2023 | 3 min read
Researchers find that small sacks inside lymph nodes contain low proteolytic activity and act as safe havens for antigens.
T Cells Ward Off Aging with Help from Their Friends
Natalia Mesa, PhD | Sep 16, 2022 | 5 min read
Immune cells deliver packages of telomeres to T cells, helping them retain their virus-fighting function over time, research suggests.
Advances in Antibody Therapeutics
Elina Kadriu | 4 min read
Scientists engineer therapeutic antibodies with improved stability and efficacy.
Are Rapid Tests Worse at Detecting Omicron—and Does It Matter?
Catherine Offord | Jan 14, 2022 | 10 min read
Anecdotal reports and results from small studies on the diagnostics’ accuracy have prompted questions about the devices’ usage with the new variant, but researchers say more data are needed and emphasize the continued importance of SARS-CoV-2 testing.
SARS-CoV-2 Antigens Leaking from Gut to Blood Might Trigger MIS-C
Alejandra Manjarrez, PhD | Jun 3, 2021 | 4 min read
Researchers find traces of SARS-CoV-2 in the stool and blood of kids with the post–COVID-19 inflammatory disorder, and signs of increased intestinal permeability.
Retraining the Immune System Cavalry for Food Allergen Peacekeeping Missions
The Scientist’s Creative Services Team | 1 min read
Explore food allergy immunotherapy for reversing patient symptoms.
The Push to Deploy At-Home Antigen Tests for COVID-19
Chris Baraniuk | Aug 17, 2020 | 5 min read
These rapid tests could allow people to find out quickly and easily if they have the disease—if they get regulatory approval for the consumer market.
Noel Rose, Who Demonstrated Autoimmunity Exists, Dies at 92
Amanda Heidt | Aug 10, 2020 | 4 min read
The Johns Hopkins University researcher bucked the prevailing idea that the body would not launch an immune response against its own tissues, and in doing so established an entirely new scientific discipline.
Technique Talk: ELISA Tips and Tricks
The Scientist’s Creative Services Team | 1 min read
Learn to optimize ELISA experiments in this workshop.
Immunology Leader Vincenzo Cerundolo Dies
Ashley Yeager | Jan 16, 2020 | 2 min read
The Oxford researcher’s work on lipid and peptide antigens revealed key mechanisms in inflammation, immunotherapy, and vaccination, which are being pursued in clinical trial treatments.
Novel Type of Immune Cell Discovered in Type 1 Diabetes Patients
Katarina Zimmer | May 30, 2019 | 6 min read
A rogue hybrid lymphocyte, bearing characteristics of both B and T cells, may play a role in driving autoimmunity in the disease, although the mechanism is far from clear.
Cancer Vaccines: Raising a T Cell Army
Niki Spahich, PhD | 1 min read
Vaccines against various forms of cancer prime the immune system to attack.
Cancer-Specific Antigens Encoded in “Junk” DNA
Carolyn Wilke | Apr 1, 2019 | 2 min read
Researchers found that allegedly noncoding genetic material carries the instructions for many peptides that may help harness the immune system to fight cancer.
Researchers Build a Cancer Immunotherapy Without Immune Cells
Abby Olena, PhD | Nov 13, 2017 | 3 min read
A team has engineered two stem cell lines into “synthetic T cells” that destroy breast cancer cells in vitro.
LabTalk Podcast - Predicting the Immune Response with Single-Cell Analysis: Autoimmunity, Vaccination, and COVID-19
The Scientist’s Creative Services Team and 10x Genomics | 1 min read
Researchers identify signatures that predict how a person will respond to an immune system stimulus.
Compound Found in Red Wine Boosts Immune Cell Function
Catherine Offord | Oct 16, 2017 | 2 min read
At low doses, resveratrol enhanced human T-cell activity in vitro, while at high doses it interfered with cell signaling.