Alzheimer's Disease

Dialing up the activity of a protein called SYK in the brain’s “janitors” could provide an avenue to treat Alzheimer’s and other neurodegenerative diseases.

The APOE4 variant causes cholesterol buildup in the cells that make protective fatty sheaths for neurons, possibly helping explain its role in neurodegeneration.

An influential paper on amyloid protein and Alzheimer’s disease potentially fabricated data. Why did it take 16 years to flag?

Damaged lysosomes are repaired by a lipid-based signaling pathway dubbed PITT that could be targeted to treat neurodegenerative disease, its discoverers say.

The Biogen-developed treatment, called lecanemab, appears to have a more clear-cut effect on slowing the disease than the company’s previous Alzheimer’s drug, Aduhelm.

Alysson R. Muotri discusses his launch of brain organoids into outer space and how microgravity enriches our understanding of brain development and disease.

Research traces the evolution of a gene variant that reduces the risk of Alzheimer’s disease, finding that it originally evolved in response to infectious bacteria.

Maligned peptides such as the Alzheimer’s-associated amyloid precursor protein may have critical roles in the healthy brain.

The normal functions of peptides that aggregate in Alzheimer’s, Parkinson’s, and Huntington’s have been largely overlooked by scientists, but some argue that they are critical for understanding the development of disease.

Researchers report molecular evidence of traumatic brain injury in headbutting animals, but other experts aren’t convinced.

Observational evidence for the connection is solidifying, and some clues are emerging about the mechanisms that may explain it.

Niacin, a form of vitamin B3 used to treat cardiovascular disease, helps immune cells in the brain fight neurodegenerative diseases such as Alzheimer’s in mice models, according to recent studies. Researchers hope that human clinical trials will swiftly follow.

A new study reveals a network of neurons that, when disrupted, impairs adaptation to new circumstances in several types of dementia.