ADVERTISEMENT
Protein structures to represent data obtained via AlphaFold
Lasker Award for Revolutionizing Protein Structure Predictions
John Jumper and Demis Hassabis received this year’s 2023 Albert Lasker Basic Medical Research Award for their work on the artificial intelligence system AlphaFold, which changed the landscape of protein biology. 
Lasker Award for Revolutionizing Protein Structure Predictions
Lasker Award for Revolutionizing Protein Structure Predictions

John Jumper and Demis Hassabis received this year’s 2023 Albert Lasker Basic Medical Research Award for their work on the artificial intelligence system AlphaFold, which changed the landscape of protein biology. 

John Jumper and Demis Hassabis received this year’s 2023 Albert Lasker Basic Medical Research Award for their work on the artificial intelligence system AlphaFold, which changed the landscape of protein biology. 

protein folding

 Dive into Cryo-EM’s History, Milestones, and Insights.
Cryo-EM: Building on a History of Invention and Innovation
Thermo Fisher Scientific | Aug 2, 2023 | 1 min read
From humble yet ingenious beginnings to Nobel recognition, cryogenic electron microscopy (cryo-EM) provides insights into scientific questions that other technologies are unable to answer.
Image of unfolded protein
My Protein Didn't Fold and Neither Did I
Meenakshi Prabhune, PhD | Aug 1, 2023 | 2 min read
When Gaurav Ghag realized that he had replicated a calculation error in every experiment during four years of his graduate research, he initially thought that his career had unraveled with his protein.  
A 3D rendering of an albumin’s protein structure.
Providing Stability In Vivo, In Vitro, and In Culture
The Scientist’s Creative Services Team and MilliporeSigma | 3 min read
Albumins enable researchers to bind, sequester, and stabilize important molecules across research applications.
Artist’s rendition of translucent teal proteins comprised of red spherical amino acids
Now AI Can Be Used to Design New Proteins
Kamal Nahas, PhD | Mar 3, 2023 | 4 min read
Machine learning can be harnessed to synthesize artificial light-bearing enzymes that actually work in cells.
A ball-and-stick plus ribbons molecular model of the hormone orexin, also known as hypocretin, isolated on a white background.
2023 Breakthrough Prizes Showcase Research in AI and Narcolepsy
Amanda Heidt | Sep 22, 2022 | 2 min read
Three prizes were awarded to six researchers working across the life sciences on cellular organization, protein structure, and the genetic underpinnings of a chronic sleep disorder.
Discover how glycosylation affects health and disease
Exploring the World of Glycobiology
The Scientist’s Creative Services Team and Vector Laboratories | 1 min read
Researchers study sugar modifications to understand health and disease.
A micrograph of the prion-like state of a protein called Pus4
Protein Mediates Non-Genetic Inheritance of Growth Strategies
Catherine Offord | Jan 4, 2022 | 2 min read
An RNA-modifying enzyme passed to daughter cells during budding allows yeast cells to switch between faster- and slower-growing phenotypes.
An illustration of a yeast cell (right) and a human neuron (left) showing the processes/features that are similar in the two
Infographic: Modeling Neurodegenerative Diseases with Yeast
Mahlon Collins | Oct 1, 2021 | 3 min read
Conservation of structures and functions between single-celled fungi and human cells allow researchers to probe the brain.
Examine Altered Glycobiology in Cancer
Examining Altered Glycobiology in Cancer
The Scientist’s Creative Services Team and Vector Laboratories | 1 min read
Changes to protein glycosylation play a major role in dictating cancer progression and prognosis, but could they also present biomarkers or therapeutic targets?
Q8W3K0, listed in the DeepMind database as a potential plant disease resistance protein from Arabidopsis thaliana
Predictions of Most Human Protein Structures Made Freely Available
Lisa Winter | Jul 23, 2021 | 3 min read
The AlphaFold program from AI firm DeepMind has amassed a huge database of protein structures from humans and model organisms.
Undone Proteins Take Out Bladder Cancer
Roni Dengler, PhD | Jul 20, 2021 | 3 min read
An unfolded protein found in human milk shows promise in early clinical trials to treat bladder cancer.
Robert “Buzz” Baldwin, Early Expert in Protein Structures, Dies
Jef Akst | Apr 2, 2021 | 2 min read
Research by the Stanford University School of Medicine professor revealed how newly formed strings of amino acids fold into complex three-dimensional shapes.
DeepMind AI Speeds Up the Time to Determine Proteins’ Structures
Lisa Winter | Dec 2, 2020 | 2 min read
The technology solves proteins’ 3-D shapes in minutes, when traditional methods may take years.
Newly Found Proteins Stop Fungal “Bleeding”
Viviane Callier | Nov 12, 2020 | 3 min read
Mechanically sensitive proteins called gellins sense and respond to protoplasm flowing out of severed hyphae, quickly sealing up injuries in these root-like structures of fungi.
“Hero” Proteins May Shield Other Proteins from Harm
Emma Yasinski | Mar 19, 2020 | 3 min read
Flexible proteins appear to protect molecules from becoming denatured in extreme conditions such as heat and from clumping up, as happens in some neurodegenerative diseases.
Scientists Use Online Game to Research COVID-19 Treatment
Emma Yasinski | Mar 9, 2020 | 3 min read
The creativity of citizen scientists could help researchers design proteins that may be able to fight the SARS-CoV-2 virus.
Detecting Protein Clumps
Ruth Williams | Feb 1, 2018 | 3 min read
A synthetic genetic tool called yTRAP allows high-throughput detection of protein aggregates in cells.
 
Drugging the Disorderome
Amber Dance | Oct 1, 2017 | 8 min read
Strategies for targeting intrinsically disordered proteins
Fascinated by Folding
Anna Azvolinsky | Aug 3, 2017 | 10 min read
Lila Gierasch uses biochemical tools to understand how linear chains of amino acids turn into complex three-dimensional structures.
ADVERTISEMENT