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Over-the-Counter Antihistamines Could Help Against Cancer
The binding of histamine with one of its receptors within the tumor environment makes cancer cells more resistant to immunotherapy, according to a new study. Blocking that binding could improve responses to treatment.
Over-the-Counter Antihistamines Could Help Against Cancer
Over-the-Counter Antihistamines Could Help Against Cancer

The binding of histamine with one of its receptors within the tumor environment makes cancer cells more resistant to immunotherapy, according to a new study. Blocking that binding could improve responses to treatment.

The binding of histamine with one of its receptors within the tumor environment makes cancer cells more resistant to immunotherapy, according to a new study. Blocking that binding could improve responses to treatment.

drug resistance

A doctor reaches out to touch a lung tumor, highlighted in red.
Silencing Epigenetic Complexes Re-sensitizes Drug-Resistant Cancer Cells
Rachael Moeller Gorman | Sep 25, 2023 | 4 min read
Researchers studying lung cancer cell lines found that chromatin remodeling underlies one type of osimertinib resistance.
illustration of colorful microbes inside a person's stomach and intestines
How Commensal Gut Bacteria Keep Pathogens in Check
Alejandra Manjarrez, PhD | Oct 14, 2021 | 7 min read
Recent studies describe how resident microbiota appear to outcompete unwelcome visitors, either with superior weaponry or by guzzling up local resources.  
Evangelos Kiskinis describes how the patient-derived iPSCs model of epilepsy help predict drug resistance.
The Scientist Speaks - Modeling Epilepsy in a Dish Using Patient-Derived iPSCs
Sejal Davla, PhD | 1 min read
Evangelos Kiskinis describes how the patient-derived iPSCs model of epilepsy help predict drug resistance.
illustration showing a microscopic view of C. auris, with clusters of round balls connected by filaments
CDC Warns of Person-to-Person Transmission of Resistant Fungus
Shawna Williams | Jul 26, 2021 | 3 min read
In a first, patients who hadn’t been treated with antifungals were found to carry Candida auris impervious to all three available classes of the drugs.
A false-colored micrograph showing swirls of yellow, red, and magenta cells
Cross-Resistance: One Cancer Therapy Can Undermine the Next
Sophie Fessl, PhD | Jul 16, 2021 | 6 min read
Targeted cancer therapy may jeopardize the effectiveness of subsequent immunotherapy by reducing dendritic cell numbers and activation, according to study of mice and patient samples.
The adaptive and innate immune responses collaborate to attack T-cell resistant cancer cells
LabTalk Podcast - Phagocidal Macrophages: A New Battle Tactic Against Resistant Cancers
The Scientist’s Creative Services Team and 10x Genomics | 1 min read
The adaptive and innate immune responses collaborate to attack T-cell resistant cancer cells.
Infographic: Researchers Take Aim at Cancer Evolution
Catherine Offord | Apr 1, 2020 | 2 min read
Strategies to trick, manipulate, and direct the evolution of tumors
Cancer Researchers Use Evolution to Target Drug Resistance
Catherine Offord | Apr 1, 2020 | 10+ min read
New therapeutic approaches in oncology aim to manipulate or block cancer’s adaptation to treatment.
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The Scientist Speaks - Homing in on New Anticancer Targets 
Sejal Davla, PhD | 1 min read
Jason Sheltzer discusses cancer mechanisms leading to drug resistance and new approaches to find drug targets.
Cancer Cells Increase DNA Mutations to Evade Treatment
Abby Olena, PhD | Nov 7, 2019 | 3 min read
Colorectal tumor cells limit their DNA repair in response to a targeted therapy, giving them a greater chance to develop resistance to the drug.
First New Tuberculosis Drug Approved in 50 Years
Jef Akst | Aug 15, 2019 | 2 min read
The US Food and Drug Administration green lights a therapy for an extreme form of multidrug resistant TB.
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Understanding Our Enemies: Identifying Mechanisms of Antibiotic Resistance
The Scientist’s Creative Services Team | 1 min read
Researchers sample and sequence bacteria from biological and environmental sources to learn how to overcome selective pressure
fecal matter transplant FDA suspend halt clinical trials patient dies died antibiotic resistance drug resistant
FDA Suspends Clinical Trials Involving Fecal Transplants
Chia-Yi Hou | Jun 14, 2019 | 1 min read
The agency issued a safety warning after two patients contracted antibiotic-resistant infections and one of the patients died.
christina cuomo candida auris
Q&A: What to Know About the Drug-Resistant Fungus, Candida auris
Emma Yasinski | Apr 18, 2019 | 3 min read
Fungal researcher Christina Cuomo discusses the spread of infections plaguing hospitals across the world.
A Connected Community: The Rise of Microbiome Research
The Scientist’s Creative Services Team | 1 min read
Explore how microbes shape health, disease, and the world beyond
malaria infographic
Infographic: Fighting Malaria Drug Resistance
Natalie Slivinski | Mar 1, 2019 | 2 min read
The parasite that causes malaria has evolved to evade many of the drugs that researchers have developed to fight the tropical disease.
malaria feature
Are We Headed for a New Era of Malaria Drug Resistance?
Natalie Slivinski | Mar 1, 2019 | 10+ min read
Plasmodium falciparum has shown an ability to evade everything we throw at it, most recently artemisinin-based combination therapies, today’s front-line treatment.
Checking Checkpoints for Treating Cancer
The Scientist’s Creative Services Team | 1 min read
Researchers devise strategies to improve checkpoint inhibitor therapy and predict patient response.
Image of the Day: Tumor Organoids
The Scientist Staff and The Scientist Staff | Apr 11, 2018 | 1 min read
Miniature versions of bladder cancers could help physicians identify personalized treatment options for patients.
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